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Brain Advance Access originally published online on September 26, 2007
Brain 2008 131(3):e91; doi:10.1093/brain/awm220
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© The Author (2007). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Parkinson's disease, sleepiness and hypocretin/orexin

Christian R. Baumann1,2, Thomas E. Scammell2 and Claudio L. Bassetti1

1Department of Neurology, University Hospital Zurich, Switzerland and 2Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine, Boston, USA

Correspondence to: Christian R. Baumann E-mail: c.r.b@swissonline.ch; christian.baumann@usz.ch

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Sir, Sleepiness and disrupted sleep substantially impair quality of life in people with Parkinson's disease (PD) (Arnulf et al., 2000Go). The hypocretin/orexin neuropeptides stabilize wakefulness and sleep, and in two recent studies, Fronczek et al. (2007Go) and Thannickal et al. (2007Go) showed that patients with late-stage PD have a 38–45% loss of the hypothalamic hypocretin-producing neurons. These studies . . . [Full Text of this Article]


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