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Brain Advance Access originally published online on June 27, 2008
Brain 2008 131(7):1681-1683; doi:10.1093/brain/awn132
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© The Author (2008). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Scientific Commentary

Do natural killer cells accelerate or prevent autoimmunity in multiple sclerosis?

Jan D. Lünemann and Christian Münz

Laboratory of Viral Immunobiology, Christopher H. Browne Center for Immunology and Immune Diseases, The Rockefeller University, Box 390, 1230 York Avenue, New York, NY 10021-6399, USA

E-mail: jlunemann@rockefeller.edu

The first 10% of the full text of this article appears below.

In an attempt to identify biomarkers, which are able to better characterize the phenotypic heterogeneity of multiple sclerosis, and at the same time dissect disease-relevant mechanisms of this autoimmune disease, de Jager and colleagues (2008) determined flow cytometric profiles of circulating blood cells from untreated patients with clinically isolated demyelinating syndrome (CIS) and relapsing–remitting multiple sclerosis (RR-MS) in comparison to healthy volunteers. Profiles were generated using a panel of 50 monoclonal antibodies which primarily targeted lymphocyte populations and were distributed amongst 56 pools of four antibodies each. The key finding of this discovery-based study was that a population of CD8dimCD4– cells was reduced in frequency in both RR-MS and CIS . . . [Full Text of this Article]


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Editorial
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Brain 2008 131: 1675-1676. [Extract] [FREE Full Text]  



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A. Lunemann, J. D. Lunemann, S. Roberts, B. Messmer, R. B. da Silva, C. S. Raine, and C. Munz
Human NK Cells Kill Resting but Not Activated Microglia via NKG2D- and NKp46-Mediated Recognition
J. Immunol., November 1, 2008; 181(9): 6170 - 6177.
[Abstract] [Full Text] [PDF]