Brain Advance Access originally published online on June 16, 2008
Brain 2008 131(7):1684-1685; doi:10.1093/brain/awn131
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
© The Author (2008). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Scientific Commentary |
Seronegative myasthenia gravis is no longer seronegative
| The first 10% of the full text of this article appears below. |
High-affinity IgG autoantibodies to muscle nicotinic acetylcholine receptors (AChRs) were discovered to cause myasthenia gravis (MG) and its animal model more than 30 years ago (Patrick and Lindstrom, 1973
; Lindstrom et al., 1976a
, b; Vincent et al., 2006
), and the antigenic structure of muscle AChRs is still being actively investigated (Kalamida et al., 2007
; Lindstrom et al., 2008
). Immune precipitation of AChRs tagged in their
Department of Neuroscience, Medical School of the University of Pennsylvania, Pennsylvania, PA, USA
E-mail: jslkk@mail.med.upenn.edu