Brain Advance Access originally published online on February 17, 2009
Brain 2009 132(3):568-569; doi:10.1093/brain/awp009
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© The Author (2009). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Scientific Commentary |
Progranulin plasma levels in the diagnosis of frontotemporal dementia
VA Puget Sound Health Care Center
University of Washington
Seattle, WA, USA
E-mail: tomnroz@u.washington.edu; vinelady@u.washington.edu
| The first 10% of the full text of this article appears below. |
Not so long ago many neurologists were trained to believe that Pick's disease was rare and usually impossible to differentiate accurately from Alzheimer's disease. Through the persistent efforts of several research groups, especially in Lund (Sweden) and Manchester (UK), it became clear that this ‘disease’ is not rare and can frequently be distinguished from Alzheimer's disease (Brun et al., 1994
). Now, this entity is better described as frontotemporal dementia (FTD) or frontotemporal lobar degeneration based on the frequent occurrence of lobar atrophy involving frontal and/or temporal lobes