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Brain Advance Access originally published online on May 8, 2009
Brain 2009 132(6):1417-1418; doi:10.1093/brain/awp121
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© The Author (2009). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Scientific Commentary

Recovery from spinal cord injury: regeneration, plasticity and rehabilitation

James W. Fawcett

Department of Clinical Neurosciences,
Cambridge University Centre for Brain Repair,
Cambridge CB2 0PY, UK
E-mail: jf108@cam.ac.uk

The first 10% of the full text of this article appears below.

Experimental spinal cord injury is no longer incurable. Many papers have appeared over the past few years reporting functional recovery following a variety of treatments. These have included interventions that affect myelin inhibitory molecules and their receptors, or inhibitory chondroitin sulphate proteoglycans, and treatments in which the regenerative potential of axons has been stimulated through growth-factor receptors or manipulation of internal signalling pathways (for reviews see Buchli and Schwab, 2005Go; Fawcett, 2006Go; Hannila et al., 2007Go). There has also been success with strategies that bridge the injury using various axon growth-promoting cell types (Fouad et al., 2005Go; Biernaskie et al., 2007Go; Raisman and Li, 2007Go). Functional recovery has been seen in hindlimbs and forelimbs and affecting walking, skilled movements, sensation and other . . . [Full Text of this Article]


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