Skip Navigation



Brain Advance Access published online on April 8, 2003
Brain, doi:10.1093/brain/awg127
© 2003 by Guarantors of Brain
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
126/6/1347    most recent
awg127v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Lassmann, H.
Right arrow Articles by Vandevelde, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lassmann, H.
Right arrow Articles by Vandevelde, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2003 The Guarantors of Brain

Article

A new paraclinical CSF marker for hypoxia-like tissue damage in multiple sclerosis lesions

Hans Lassmann 1*, Markus Reindl 2, Helmut Rauschka 3, Johannes Berger 1, Fahmy Aboul-Enein 1, Thomas Berger 2, Andreas Zurbriggen 4, Andreas Lutterotti 2, Wolfgang Brück 5, Jörg R. Weber 6, Robert Ullrich 7, Manfred Schmidbauer 3, Kurt Jellinger 8, Marc Vandevelde 4

1 Brain Research Institute, University of Vienna, Austria
2 Department of Neurology, University of Innsbruck, Innsbruck, Austria
3 Department of Neurology, Hospital Lainz, Vienna, Austria
4 Department of Clinical Veterinary Medicine, University of Berne, Berne, Switzerland
5 Department of Neuropathology, Charite, Berlin, Germany
6 Department of Neurology, Charite, Berlin, Germany
7 Department of Clinical Pathology, University of Vienna, Austria
8 Ludwig Boltzmann Institute for Clinical Neurobiology, Vienna, Austria

* Corresponding author. E-mail: hans.lassmann{at}univie.ac.at.

Received 24 September 2002 ; revised 20 December 2002 ; accepted 27 December 2002

Abstract

Recent studies on the immunopathology of multiple sclerosis revealed a heterogeneity in the patterns of demyelination, suggesting interindividual differences in the mechanism responsible for myelin destruction. One of these patterns of demyelination, characterized by oligodendrocyte dystrophy and apoptosis, closely mimics myelin destruction in acute white matter ischaemia. In the course of a systematic screening for virus antigen expression in multiple sclerosis brains, we identified a monoclonal antibody against canine distemper virus, which detects a cross-reactive endogenous brain epitope, highly expressed in this specific subtype of actively demyelinating multiple sclerosis lesions with little or no immunoreactivity in other active multiple sclerosis cases. The respective epitope, which is a phosphorylation-dependent sequence of one or more proteins of 50, 70 and 115 kDa, is also expressed in a subset of active lesions of different virus-induced inflammatory brain diseases, but is present most prominently and consistently in acute lesions of white matter ischaemia. Its presence is significantly associated with nuclear expression of hypoxia-inducible factor-1{alpha} within the lesions of both inflammatory and ischaemic brain diseases. The respective epitope is liberated into the CSF and, thus, may become a useful diagnostic tool to identify clinically a defined multiple sclerosis subtype.

Keywords: multiple sclerosis; demyelination; hypoxia; cerebrospinal fluid; canine distemper
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mult SclerHome page
J N. Zwemmer, J Berkhof, J A Castelijns, F Barkhof, C H Polman, and B M. Uitdehaag
Classification of multiple sclerosis patients by latent class analysis of magnetic resonance imaging characteristics
Multiple Sclerosis, September 1, 2006; 12(5): 565 - 572.
[Abstract] [PDF]

Home page
 Am. J. Neuroradiol.Home page
C. Rosso, P. Remy, A. Creange, P. Brugieres, P. Cesaro, and H. Hosseini
Diffusion-Weighted MR Imaging Characteristics of an Acute Strokelike Form of Multiple Sclerosis.
AJNR Am. J. Neuroradiol., May 1, 2006; 27(5): 1006 - 1008.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. Krumbholz, D. Theil, S. Cepok, B. Hemmer, P. Kivisakk, R. M. Ransohoff, M. Hofbauer, C. Farina, T. Derfuss, C. Hartle, et al.
Chemokines in multiple sclerosis: CXCL12 and CXCL13 up-regulation is differentially linked to CNS immune cell recruitment
Brain, January 1, 2006; 129(1): 200 - 211.
[Abstract] [Full Text] [PDF]

Home page
 Mult SclerHome page
L. Airas, T. Kurki, H. Erjanti, and R. J Marttila
Successful pregnancy of a patient with Balo's concentric sclerosis
Multiple Sclerosis, June 1, 2005; 11(3): 346 - 348.
[Abstract] [PDF]

Home page
 BrainHome page
S. Love
Establishing preconditions for Balo's concentric sclerosis
Brain, May 1, 2005; 128(5): 960 - 962.
[Full Text] [PDF]

Home page
 BrainHome page
C. Stadelmann, S. Ludwin, T. Tabira, A. Guseo, C. F. Lucchinetti, L. Leel-Ossy, A. T. Ordinario, W. Bruck, and H. Lassmann
Tissue preconditioning may explain concentric lesions in Balo's type of multiple sclerosis
Brain, May 1, 2005; 128(5): 979 - 987.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
B. Bielekova and R. Martin
Development of biomarkers in multiple sclerosis
Brain, July 1, 2004; 127(7): 1463 - 1478.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.