Skip Navigation



Brain Advance Access published online on May 21, 2003
Brain, doi:10.1093/brain/awg165
© 2003 by Guarantors of Brain
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
126/7/1562    most recent
awg165v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Naito, Y.
Right arrow Articles by Ito, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Naito, Y.
Right arrow Articles by Ito, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© 2003 The Guarantors of Brain

Article

Cortical correlates of vestibulo-ocular reflex modulation: a PET study

Yasushi Naito 1*, Ichiro Tateya 1, Shigeru Hirano 1, Masato Inoue 1, Kazuo Funabiki 1, Hiroshi Toyoda 2, Makoto Ueno 2, Koichi Ishizu 2, Yasuhiro Nagahama 3, Hidenao Fukuyama 3, Juichi Ito 1

1 Department of Otolaryngology - Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
2 Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan
3 Human Brain Research Center, Graduate School of Medicine, Kyoto University, Kyoto, Japan

* Corresponding author. E-mail: naito{at}ent.kuhp.kyoto-u.ac.jp.

Received 18 July 2002 ; revised 3 January 2003 ; accepted 12 March 2003

Abstract

To elucidate cortical correlates of vestibulo-ocular reflex (VOR) modulation, we observed cortical activation during fixation suppression and habituation of caloric vestibular nystagmus in 12 normal subjects, using PET. Significant positive correlation between regional cerebral blood flow (rCBF) and slow phase eye velocity of caloric nystagmus was observed in the middle and posterior insula, inferior parietal lobule, temporal pole, right fusiform gyrus, lingual gyrus, and cerebellar vermis and hemisphere. The rCBF increase in the insular region and the inferior parietal lobule was lateralized depending on the direction of the nystagmus. Caloric nystagmus was suppressed as a result of visual fixation, during which time the area around the right frontal eye field, temporal pole, inferior temporal gyrus, a broad area in the visual cortex, including fusiform and lingual gyrus, cerebellar uvula/nodulus and flocculus, exhibited positive correlation with fixation suppression of caloric nystagmus, while vestibular cortices exhibited negative correlation. The caloric nystagmus habituated with repetition of stimulation. With habituation, we observed activation in the right anterior cingulate gyrus, left superior parietal lobule and right cuneus, and deactivation in the anterior insula, cingulate gyrus, inferior parietal lobule and occipito-temporal visual cortex. The region that showed significant co-activation with fixation suppression and habituation of caloric nystagmus was the right cuneus, and significant co-deactivation was observed in the anterior insula, cingulate gyrus, inferior parietal lobule and middle temporal visual cortex. The present results support previous observations that the parieto-insular cortex and inferior parietal lobule are involved in processing of vestibular information, and, in addition, suggest that activation may depend on the direction of nystagmus. Deactivation of vestibular cortices during visual fixation supports the concept of inhibitory visual-vestibular interaction in the cortex. Significant activation of the cingulate, superior parietal and visual cortices, and cerebellar vermis accompanying reduction of caloric response with repeated stimuli suggests possible involvement of these regions in vestibular habituation. Common activation of the cuneus in visual cortex and deactivation of vestibular and visuo-spatial association cortices by both visual suppression and habituation of VOR suggests that these two mechanisms are not completely independent but may share some cortical and subcortical regions.

Keywords: caloric nystagmus; fixation suppression; PET; vestibular habituation; visual-vestibular interaction
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 BrainHome page
B. Baier, P. Stoeter, and M. Dieterich
Anatomical correlates of ocular motor deficits in cerebellar lesions
Brain, August 1, 2009; 132(8): 2114 - 2124.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
P D McGeoch, L E Williams, R R Lee, and V S Ramachandran
Behavioural evidence for vestibular stimulation as a treatment for central post-stroke pain
J. Neurol. Neurosurg. Psychiatry, November 1, 2008; 79(11): 1298 - 1301.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
M. Dieterich and T. Brandt
Functional brain imaging of peripheral and central vestibular disorders
Brain, October 1, 2008; 131(10): 2538 - 2552.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurophysiol.Home page
W. L. Miller, V. Maffei, G. Bosco, M. Iosa, M. Zago, E. Macaluso, and F. Lacquaniti
Vestibular Nuclei and Cerebellum Put Visual Gravitational Motion in Context
J Neurophysiol, April 1, 2008; 99(4): 1969 - 1982.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.