Brain Advance Access published online on June 23, 2003
Brain, doi:10.1093/brain/awg196
© 2003 by Guarantors of Brain
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Article
1 INSERM E0218-Université de Caen, GIP Cyceron, CHU Côte de Nacre, France
* Corresponding author. E-mail: neuropsycho{at}chu-caen.fr.
Received 5 August 2002
; revised 9 February 2003
; accepted 11 April 2003
The present study aims to unravel, in the same study, both morphological and functional specific substrates of encoding versus retrieval deficits in patients with amnestic mild cognitive impairment (MCI). For this purpose, 21 highly screened MCI patients with isolated memory impairment, who attended a memory clinic and fulfilled operational criteria for MCI, underwent (i) two episodic memory subtests designed to assess preferentially either incidental encoding or retrieval capacity; (ii) a high-resolution T1-weighted volume MRI scan; and (iii) a resting state [18F]fluoro-2-deoxy-D-glucose PET study. Using statistical parametic mapping, positive correlations between memory scores on one hand, and grey matter density and normalized partial volume effect-corrected brain glucose utilization (ncCMRglc) on the other hand, were computed. Deficits in both encoding and retrieval were correlated with declines in hippocampal region grey matter density. The encoding subtest also correlated with hippocampal ncCMRglc, whereas the retrieval subtest correlated with the posterior cingulate area ncCMRglc only. The present findings highlight a distinction in the neural substrates of encoding and retrieval deficits in MCI. Furthermore, they unravel a partial dissociation between metabolic and structural correlates, suggesting distinct interpretations. Hippocampal atrophy was related to both encoding and retrieval deficits, possibly reflecting a direct effect on hippocampal functioning, as well as an indirect effect, through remote functional disruption, on posterior cingulate region synaptic function, respectively.
Keywords: Alzheimer's disease; resting cerebral glucose metabolism; MRI; statistical parametric mapping; episodic memory
Dissociating atrophy and hypometabolism impact on episodic memory in mild cognitive impairment
2 INSERM E0218-Université de Caen, GIP Cyceron, CHU Côte de Nacre; Services de Neurologie, CHU de Caen, France
3 INSERM E0218-Université de Caen, GIP Cyceron, CHU Côte de Nacre; PVE-OUT EC project, France
4 Services de Neurologie, CHU de Caen, France
5 CH de Cherbourg, France
6 CHU de Rouen, France
7 Services de Neurologie, CHU de Caen, France; Department of Neurology, University of Cambridge, Cambridge, UK
8 INSERM E0218-Université de Caen, GIP Cyceron, CHU Côte de Nacre; Ecole Pratique des Hautes Etudes, CNRS 8581, Université René Descartes, Paris 5, France
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  G. Chetelat, N. Villain, B. Desgranges, F. Eustache, and J.-C. Baron Posterior cingulate hypometabolism in early Alzheimer's disease: what is the contribution of local atrophy versus disconnection? Brain, October 25, 2009; (2009) awp253v1. [Full Text] [PDF]
|
|
|
|
|
|
A. T.-D. Fonseca, E. Guedj, F-X. Alario, V. Laguitton, O. Mundler, P. Chauvel, and C. Liegeois-Chauvel Brain regions underlying word finding difficulties in temporal lobe epilepsy Brain, October 1, 2009; 132(10): 2772 - 2784. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Fouquet, B. Desgranges, B. Landeau, E. Duchesnay, F. Mezenge, V. de la Sayette, F. Viader, J.-C. Baron, F. Eustache, and G. Chetelat Longitudinal brain metabolic changes from amnestic mild cognitive impairment to Alzheimer's disease Brain, August 1, 2009; 132(8): 2058 - 2067. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Xu, D. G. Mclaren, M. L. Ries, M. E. Fitzgerald, B. B. Bendlin, H. A. Rowley, M. A. Sager, C. Atwood, S. Asthana, and S. C. Johnson The influence of parental history of Alzheimer's disease and apolipoprotein E {varepsilon}4 on the BOLD signal during recognition memory Brain, February 1, 2009; 132(2): 383 - 391. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Luerding, T. Weigand, U. Bogdahn, and T. Schmidt-Wilcke Working memory performance is correlated with local brain morphology in the medial frontal and anterior cingulate cortex in fibromyalgia patients: structural correlates of pain-cognition interaction Brain, December 1, 2008; 131(12): 3222 - 3231. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Villain, B. Desgranges, F. Viader, V. de la Sayette, F. Mezenge, B. Landeau, J.-C. Baron, F. Eustache, and G. Chetelat Relationships between Hippocampal Atrophy, White Matter Disruption, and Gray Matter Hypometabolism in Alzheimer's Disease J. Neurosci., June 11, 2008; 28(24): 6174 - 6181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Karas, J. Sluimer, R. Goekoop, W. van der Flier, S.A.R.B. Rombouts, H. Vrenken, P. Scheltens, N. Fox, and F. Barkhof Amnestic Mild Cognitive Impairment: Structural MR Imaging Findings Predictive of Conversion to Alzheimer Disease AJNR Am. J. Neuroradiol., May 1, 2008; 29(5): 944 - 949. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Chetelat, B. Desgranges, B. Landeau, F. Mezenge, J. B. Poline, V. de la Sayette, F. Viader, F. Eustache, and J.-C. Baron Direct voxel-based comparison between grey matter hypometabolism and atrophy in Alzheimer's disease Brain, January 1, 2008; 131(1): 60 - 71. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Viard, P. Piolino, B. Desgranges, G. Chetelat, K. Lebreton, B. Landeau, A. Young, V. De La Sayette, and F. Eustache Hippocampal Activation for Autobiographical Memories over the Entire Lifetime in Healthy Aged Subjects: An fMRI Study Cereb Cortex, October 1, 2007; 17(10): 2453 - 2467. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Truchot, S. N. Costes, L. Zimmer, B. Laurent, D. Le Bars, C. Thomas-Anterion, B. Croisile, B. Mercier, M. Hermier, A. Vighetto, et al. Up-regulation of hippocampal serotonin metabolism in mild cognitive impairment Neurology, September 4, 2007; 69(10): 1012 - 1017. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F Portet, P J Ousset, P J Visser, G B Frisoni, F Nobili, P. Scheltens, B Vellas, J Touchon, and the MCI Working Group of the European Consortium o Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer's Disease J. Neurol. Neurosurg. Psychiatry, June 1, 2006; 77(6): 714 - 718. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. C. H. Lee, M. J. Buckley, D. Gaffan, T. Emery, J. R. Hodges, and K. S. Graham Differentiating the roles of the hippocampus and perirhinal cortex in processes beyond long-term declarative memory: a double dissociation in dementia. J. Neurosci., May 10, 2006; 26(19): 5198 - 5203. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Marcos, P. Gil, A. Barabash, R. Rodriguez, M. Encinas, C. Fernandez, and J. A. Cabranes Neuropsychological Markers of Progression From Mild Cognitive Impairment to Alzheimer's Disease American Journal of Alzheimer's Disease and Other Dementias, May 1, 2006; 21(3): 189 - 196. [Abstract] [PDF]
|
|
|
|
 |
|
 L. G. Apostolova, R. A. Dutton, I. D. Dinov, K. M. Hayashi, A. W. Toga, J. L. Cummings, and P. M. Thompson Conversion of Mild Cognitive Impairment to Alzheimer Disease Predicted by Hippocampal Atrophy Maps Arch Neurol, May 1, 2006; 63(5): 693 - 699. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Goekoop, P. Scheltens, F. Barkhof, and S. A. R. B. Rombouts Cholinergic challenge in Alzheimer patients and mild cognitive impairment differentially affects hippocampal activation--a pharmacological fMRI study Brain, January 1, 2006; 129(1): 141 - 157. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Mosconi, W. -H. Tsui, S. De Santi, J. Li, H. Rusinek, A. Convit, Y. Li, M. Boppana, and M. J. de Leon Reduced hippocampal metabolism in MCI and AD: Automated FDG-PET image analysis Neurology, June 14, 2005; 64(11): 1860 - 1867. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Missonnier, G. Gold, L. Fazio-Costa, J.-P. Michel, R. Mulligan, A. Michon, V. Ibanez, and P. Giannakopoulos Early Event-Related Potential Changes During Working Memory Activation Predict Rapid Decline in Mild Cognitive Impairment J. Gerontol. A Biol. Sci. Med. Sci., May 1, 2005; 60(5): 660 - 666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. A. Johnson, G.-H. Jahng, M. W. Weiner, B. L. Miller, H. C. Chui, W. J. Jagust, M. L. Gorno-Tempini, and N. Schuff Pattern of Cerebral Hypoperfusion in Alzheimer Disease and Mild Cognitive Impairment Measured with Arterial Spin-labeling MR Imaging: Initial Experience Radiology, March 1, 2005; 234(3): 851 - 859. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.K. Panegyres The contribution of the study of neurodegenerative disorders to the understanding of human memory QJM, September 1, 2004; 97(9): 555 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Grossman, C. McMillan, P. Moore, L. Ding, G. Glosser, M. Work, and J. Gee What's in a name: voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer's disease, frontotemporal dementia and corticobasal degeneration Brain, March 1, 2004; 127(3): 628 - 649. [Abstract] [Full Text] [PDF]
|
|