Brain Advance Access published online on July 22, 2003
Brain, doi:10.1093/brain/awg247
© 2003 by Guarantors of Brain
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Article
1 Neural Development Unit, Institute of Child Health, University College London, London, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
* Corresponding author. E-mail: simon.fisher{at}well.ox.ac.uk.
Received 11 April 2003
; revised 28 May 2003
; accepted 29 May 2003
Disruption of FOXP2, a gene encoding a forkhead-domain transcription factor, causes a severe developmental disorder of verbal communication, involving profound articulation deficits, accompanied by linguistic and grammatical impairments. Investigation of the neural basis of this disorder has been limited previously to neuroimaging of affected children and adults. The discovery of the gene responsible, FOXP2, offers a unique opportunity to explore the relevant neural mechanisms from a molecular perspective. In the present study, we have determined the detailed spatial and temporal expression pattern of FOXP2 mRNA in the developing brain of mouse and human. We find expression in several structures including the cortical plate, basal ganglia, thalamus, inferior olives and cerebellum. These data support a role for FOXP2 in the development of corticostriatal and olivocerebellar circuits involved in motor control. We find intriguing concordance between regions of early expression and later sites of pathology suggested by neuroimaging. Moreover, the homologous pattern of FOXP2/Foxp2 expression in human and mouse argues for a role for this gene in development of motor-related circuits throughout mammalian species. Overall, this study provides support for the hypothesis that impairments in sequencing of movement and procedural learning might be central to the FOXP2-related speech and language disorder.
Keywords: FOXP2; speech and language disorder; RNA expression; motor system; brain development
FOXP2 expression during brain development coincides with adult sites of pathology in a severe speech and language disorder
2 Neural Development Unit, Institute of Child Health, University College London, London, UK
3 Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. B. Tomblin, M. O'Brien, L. D. Shriberg, C. Williams, J. Murray, S. Patil, J. Bjork, S. Anderson, and K. Ballard Language Features in a Mother and Daughter of a Chromosome 7;13 Translocation Involving FOXP2 J Speech Lang Hear Res, October 1, 2009; 52(5): 1157 - 1174. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. C. Vernes, D. F. Newbury, B. S. Abrahams, L. Winchester, J. Nicod, M. Groszer, M. Alarcon, P. L. Oliver, K. E. Davies, D. H. Geschwind, et al. A Functional Genetic Link between Distinct Developmental Language Disorders N. Engl. J. Med., November 27, 2008; 359(22): 2337 - 2345. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Itakura, A. Chandra, Z. Yang, X. Xue, B. Wang, W. Kimura, K. Hikosaka, K. Inohaya, A. Kudo, T. Uezato, et al. The Medaka FoxP2, a Homologue of Human Language Gene FOXP2, has a Diverged Structure and Function J. Biochem., March 1, 2008; 143(3): 407 - 416. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Fujita, Y. Tanabe, A. Shiota, M. Ueda, K. Suwa, M. Y. Momoi, and T. Momoi Ultrasonic vocalization impairment of Foxp2 (R552H) knockin mice related to speech-language disorder and abnormality of Purkinje cells PNAS, February 26, 2008; 105(8): 3117 - 3122. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. R. Dawe, U. M. Smith, A. R. Cullinane, D. Gerrelli, P. Cox, J. L. Badano, S. Blair-Reid, N. Sriram, N. Katsanis, T. Attie-Bitach, et al. The Meckel-Gruber Syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation Hum. Mol. Genet., January 15, 2007; 16(2): 173 - 186. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Vernes, J. Nicod, F. M. Elahi, J. A. Coventry, N. Kenny, A.-M. Coupe, L. E. Bird, K. E. Davies, and S. E. Fisher Functional genetic analysis of mutations implicated in a human speech and language disorder Hum. Mol. Genet., November 1, 2006; 15(21): 3154 - 3167. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. A. White, S. E. Fisher, D. H. Geschwind, C. Scharff, and T. E. Holy Singing Mice, Songbirds, and More: Models for FOXP2 Function and Dysfunction in Human Speech and Language J. Neurosci., October 11, 2006; 26(41): 10376 - 10379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. A. Seger The Basal Ganglia in Human Learning Neuroscientist, August 1, 2006; 12(4): 285 - 290. [Abstract] [PDF]
|
|
|
|
|
|
I. Teramitsu and S. A. White FoxP2 regulation during undirected singing in adult songbirds. J. Neurosci., July 12, 2006; 26(28): 7390 - 7394. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Paracchini, A. Thomas, S. Castro, C. Lai, M. Paramasivam, Y. Wang, B. J. Keating, J. M. Taylor, D. F. Hacking, T. Scerri, et al. The chromosome 6p22 haplotype associated with dyslexia reduces the expression of KIAA0319, a novel gene involved in neuronal migration Hum. Mol. Genet., May 15, 2006; 15(10): 1659 - 1666. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. H. Bak, D. Yancopoulou, P. J. Nestor, J. H. Xuereb, M. G. Spillantini, F. Pulvermuller, and J. R. Hodges Clinical, imaging and pathological correlates of a hereditary deficit in verb and action processing Brain, February 1, 2006; 129(2): 321 - 332. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Shu, J. Y. Cho, Y. Jiang, M. Zhang, D. Weisz, G. A. Elder, J. Schmeidler, R. De Gasperi, M. A. G. Sosa, D. Rabidou, et al. Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene PNAS, July 5, 2005; 102(27): 9643 - 9648. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. M. Webb and J. Zhang FoxP2 in Song-Learning Birds and Vocal-Learning Mammals J. Hered., May 1, 2005; 96(3): 212 - 216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Teramitsu, L. C. Kudo, S. E. London, D. H. Geschwind, and S. A. White Parallel FoxP1 and FoxP2 Expression in Songbird and Human Brain Predicts Functional Interaction J. Neurosci., March 31, 2004; 24(13): 3152 - 3163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Haesler, K. Wada, A. Nshdejan, E. E. Morrisey, T. Lints, E. D. Jarvis, and C. Scharff FoxP2 Expression in Avian Vocal Learners and Non-Learners J. Neurosci., March 31, 2004; 24(13): 3164 - 3175. [Abstract] [Full Text] [PDF]
|
|