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Brain Advance Access published online on December 22, 2003
Brain, doi:10.1093/brain/awh067
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Article

The cognitive ability of an incident cohort of Parkinson’s patients in the UK. The CamPaIGN study

Thomas Foltynie ^1*, Carol E. G. Brayne ², Trevor W. Robbins ³, and Roger A. Barker ¹

¹ Cambridge Centre for Brain Repair, Cambridge CB2 2PY, UK
² Department of Public Health and Primary Care, Institute of Public Health, Cambridge CB2 2PY, UK
³ Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge, CB2 2PY, UK

^* Corresponding author. E-mail: tf210{at}medschl.cam.ac.uk.

Received 1 August 2003 ; revised 21 August 2003 ; accepted 23 October 2003

Abstract

We have used multiple sources to identify a population-representative cohort of newly diagnosed patients with parkinsonism and Parkinson’s disease in the UK over a 2-year period. All patients have been invited to participate in a detailed clinical assessment either at home or in an outpatient clinic. These assessments have been used to refine clinical diagnoses of parkinsonism using established criteria, and describe some of the phenotypic variability of Parkinson’s disease at the time of diagnosis. The crude incidence of Parkinson’s disease was 13.6/10^5yr-1 [confidence interval (CI) 11.8-15.6 and of parkinsonism was 20.9/10^5yr-1 (CI 18.7-23.3). Age-standardized to the 1991 European population, the incidence figures become 10.8/10^5yr-1 (CI 9.4-12.4) for Parkinson’s disease and 16.6/10^5yr-1 (CI 14.8-18.6) for parkinsonism. Thirty-six per cent of the Parkinson’s disease patients had evidence of cognitive impairment based on their performance in the Mini-Mental State Examination, a pattern recognition task, and the Tower of London task. The pattern of cognitive deficits seen among these patients using these and further cognitive tasks suggests that sub-groups of patients based on cognitive ability might be identifiable even in the early stages of disease, which may reflect regional differences in the underlying neuropathological processes.

Keywords: incidence; Parkinson’s disease; parkinsonism; cognitive
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