Brain Advance Access published online on October 20, 2004
Brain, doi:10.1093/brain/awh296
© 2004 by Guarantors of Brain
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 University of Toronto, Toronto, ON, Canada; Department of Psychiatry, Traumatic Brain Injury Clinic, Sunnybrook and Women's College Health Sciences Centre, Toronto, ON, Canada
* To whom correspondence should be addressed. Summary The possession of at least one APOE-
Revised July 5, 2004
Accepted July 28, 2004
Article
Six-month recovery from mild to moderate Traumatic Brain Injury: the role of APOE-
4 allele
2 University of Toronto, Toronto, ON, Canada; Department of Clinical Pathology, Sunnybrook and Women's College Health Sciences Centre, Toronto, ON, Canada
Anthony Feinstein, E-mail: loricham{at}yahoo.com
Abstract 
4 allele may be linked to poor outcome in patients with predominantly severe traumatic brain injury (TBI). In mild TBI, which accounts for approximately 85% of all cases, the role of the APOE-4 allele is less clear. Studies completed to date have relied on brief cognitive assessments or coarse measures of global functioning, thereby limiting their conclusions. Our study investigated the influence of the APOE-4 allele in a prospective sample of 90 adults with mild to moderate TBI in whom neuropsychiatric outcome 6 months after injury was assessed as follows: (i) a detailed neuropsychological battery; (ii) an index of emotional distress (General Health Questionnaire); (iii) a diagnosis of major depression (Structured Clinical Interview for DSM-IV); (iv) a measure of global functioning (Glasgow Outcome Scale); (v) an index of psychosocial outcome (Rivermead Head Injury Follow-up Questionnaire); and (vi) symptoms of persistent post-concussion disorder (Rivermead Post-Concussion Symptoms Questionnaire). No association was found between the presence of the APOE-4 allele and poor outcome across all measures. Given the homogeneous nature of our sample (mild to moderate injury severity), the uniform follow-up period (6 months) and the comprehensive markers of recovery used, our data suggest that the APOE-4 allele does not adversely impact outcome in this group of TBI patients.4 allele; cognitive testing; mood; psychosocial outcome; head injury.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A H P W.-v. Son, G M Ribbers, W C J Hop, C M van Duijn, and H J Stam Association between apolipoprotein-{varepsilon}4 and long-term outcome after traumatic brain injury J. Neurol. Neurosurg. Psychiatry, April 1, 2008; 79(4): 426 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rapoport, U. Wolf, N. Herrmann, A. Kiss, P. Shammi, M. Reis, A. Phillips, and A. Feinstein Traumatic Brain Injury, Apolipoprotein E-{epsilon}4, and Cognition in Older Adults: A Two-Year Longitudinal Study J Neuropsychiatry Clin Neurosci, February 1, 2008; 20(1): 68 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S D. Han, A. I Drake, L. M Cessante, A. J Jak, W. S Houston, D. C Delis, J V. Filoteo, and M. W Bondi Apolipoprotein E and traumatic brain injury in a military population: evidence of a neuropsychological compensatory mechanism? J. Neurol. Neurosurg. Psychiatry, October 1, 2007; 78(10): 1103 - 1108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Ponsford, D. Rudzki, K. Bailey, and K. T. Ng Impact of apolipoprotein gene on cognitive impairment and recovery after traumatic brain injury Neurology, February 20, 2007; 68(8): 619 - 620. [Full Text] [PDF]
|
|
|
|
|
|
M Ariza, R Pueyo, M d. M Matarin, C Junque, M Mataro, I Clemente, P Moral, M A Poca, A Garnacho, and J Sahuquillo Influence of APOE polymorphism on cognitive and behavioural outcome in moderate and severe traumatic brain injury J. Neurol. Neurosurg. Psychiatry, October 1, 2006; 77(10): 1191 - 1193. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. W. Mahley, K. H. Weisgraber, and Y. Huang Inaugural Article: Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease PNAS, April 11, 2006; 103(15): 5644 - 5651. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z.-S. Ji, K. Mullendorff, I. H. Cheng, R. D. Miranda, Y. Huang, and R. W. Mahley Reactivity of Apolipoprotein E4 and Amyloid beta Peptide: LYSOSOMAL STABILITY AND NEURODEGENERATION J. Biol. Chem., February 3, 2006; 281(5): 2683 - 2692. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. M. Teasdale, G. D. Murray, and J. A. R. Nicoll The association between APOE {varepsilon}4, age and outcome after head injury: a prospective cohort study Brain, November 1, 2005; 128(11): 2556 - 2561. [Abstract] [Full Text] [PDF]
|
|