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Brain Advance Access published online on February 23, 2005
Brain, doi:10.1093/brain/awh442
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© The Author (2005). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received November 5, 2004
Revised January 10, 2005
Accepted January 18, 2005

Article

Subdural recordings of the mismatch negativity (MMN) in patients with focal epilepsy

Timm Rosburg 1*, Peter Trautner 1, Thomas Dietl 1, Oleg A. Korzyukov 2, Nashaat N. Boutros 2, Carlo Schaller 3, Christian Erich Elger 1, and Martin Kurthen 1

1 Department of Epileptology, University of Bonn, Germany
2 Yale University, School of Medicine, Department of Psychiatry, West Haven, USA
3 Department of Neurosurgery, University of Bonn, Germany

* To whom correspondence should be addressed.
Timm Rosburg, E-mail: timm.rosburg{at}ukb.uni-bonn.de


  Abstract

Summary Mismatch negativity (MMN) is elicited by discernible changes in an otherwise regular stream of auditory stimulation and reflects a pre-attentive detection mechanism. In the current study, auditory evoked potentials were recorded intracranially and electrode contacts sensitive for stimulus deviance were selected in order to further elucidate the contribution of different brain areas to MMN generation. Data were obtained from patients with frontal and temporal lobe epilepsy undergoing a presurgical evaluation by subdural and depth electrodes. In 13 of 29 patients under investigation an intracranial MMN could be observed, while in four other patients a response recovery of the N100 was revealed, mimicking an MMN. Most electrodes with an MMN signal were located in or close to the superior temporal lobe. In two patients an MMN was observed at electrode contacts over the lateral inferior frontal cortex and in one patient at a frontal interhemispheric electrode strip, giving evidence for a participation of the frontal gyrus in MMN generation. Current findings have, however, to be interpreted with caution owing to the placement and limited extension of the used electrode arrays.

Keywords: auditory evoked potentials; mismatch negativity; attention; auditory memory; frontal cortex.
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