Brain Advance Access published online on February 23, 2005
Brain, doi:10.1093/brain/awh446
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1 Department of Neurology, McGill University, Montreal, Quebec, Canada; Department of Neurosurgery, McGill University, Montreal, Quebec, Canada; Scuola di Specializzazione di Neurologia, Università degli Studi di Messina, Italy
Summary Activation of specific cortical territories by sensory stimuli or of less restricted areas of the brain by cognitive stimuli is known to induce apparently generalized seizures in predisposed patients; this is clinically and electroencephalographically distinct from reflex triggering of partial seizures. Photosensitive patients may have seizures when exposed to environmental stimuli producing appropriate flickering light or geometric patterns. Some children with benign myoclonic epilepsy in infancy have seizures triggered by unexpected touch or noise. Seizures induced by thinking have been reported in response to non-verbal higher mental activity such as mental arithmetic. Praxis-induced seizures are triggered by similar mental activities accompanied by the use of the hands. Language-induced seizures are usually triggered by verbal higher mental activity. Functional imaging and other methods have contributed to understanding how these seizures arise. Patients with these generalized reflex seizures appear to have regions of cortical hyperexcitability overlapping or coinciding with areas physiologically activated during specific sensory stimulations and cognitive or motor activities. When these areas receive appropriate afferent volleys and a critical mass of cortex is activated, an epileptic activity is produced that ultimately involves cortico-reticular or cortico-cortical pathways resulting in a generalized or bilateral epileptic event.
Received July 25, 2004
Revised January 16, 2005
Accepted January 18, 2005
Review Article
Cortical triggers in generalized reflex seizures and epilepsies
2 Epilepsy Clinic, Montreal Neurological Hospital and Institute, Montreal, Quebec, Canada
3 Department of Neurology, McGill University, Montreal, Quebec, Canada; Department of Neurosurgery, McGill University, Montreal, Quebec, Canada; Human Genetics McGill University, Montreal, Quebec, Canada
4 Department of Neurology, McGill University, Montreal, Quebec, Canada; Department of Neurosurgery, McGill University, Montreal, Quebec, Canada; Pediatrics, McGill University Montreal, Quebec, Canada; Epilepsy Clinic, Montreal Neurological Hospital and Institute, Montreal, Quebec, Canada
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