Skip Navigation



Brain Advance Access published online on April 20, 2005
Brain, doi:10.1093/brain/awh508
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
128/6/1259    most recent
awh508v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Cordato, N. J.
Right arrow Articles by Pantelis, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cordato, N. J.
Right arrow Articles by Pantelis, C.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author (2005). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org
Received April 29, 2004
Revised January 30, 2005
Accepted March 11, 2005

Article

Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy

N. J. Cordato 1*, A. J. Duggins 2, G. M. Halliday 3, J. G. L. Morris 2, and C. Pantelis 4

1 Department of Geriatric Medicine, Westmead Hospital and the University of Sydney, NSW, Australia
2 Department of Neurology, Westmead Hospital, Westmead, NSW, Australia
3 Prince of Wales Medical Research Institute and the University of New South Wales, Sydney, NSW, Australia
4 Melbourne Neuropsychiatry Centre, The University of Melbourne, Royal Melbourne and Sunshine Hospitals, Victoria Australia

* To whom correspondence should be addressed.
N. J. Cordato, E-mail: Nicholas_Cordato{at}wsahs.nsw.gov.au


  Abstract

Summary Most cerebral imaging studies of patients with progressive supranuclear palsy (PSP) have noted subtle atrophy, although the full extent of atrophy and any correlates to clinical features have not been determined. We used voxel-based morphometry analysis of grey matter, white matter and CSF on MRI brain scans to map the statistical probability of regional tissue atrophy in 21 patients with PSP, 17 patients with Parkinson's disease and 23 controls. PSP and Parkinson's disease cohorts were selected to approximate the mid-stages of their respective disease courses. Where regions of significant tissue atrophy were identified in a disease group relative to controls, the probability of tissue loss within those regions was correlated with global indices of motor disability, and behavioural and cognitive disturbance for that disease group. Minimal regional atrophy was observed in Parkinson's disease. PSP could be distinguished from both controls and Parkinson's disease by symmetrical tissue loss in the frontal cortex (maximal in the orbitofrontal and medial frontal cortices), subcortical nuclei (midbrain, caudate and thalamic) as well as periventricular white matter. For PSP, motor deficits correlated with atrophy of the caudate and motor cingulate, while behavioural changes related to atrophy in the orbitofrontal cortex and midbrain. These data suggest that intrinsic neurodegeneration of specific subcortical nuclei and frontal cortical subregions together contribute to motor and behavioural disturbances in PSP and differentiate this disorder from Parkinson's disease within 2-4 years of symptom onset.

Keywords: Parkinson's disease; progressive supranuclear palsy; regional brain atrophy; voxel-based morphometry.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Neurol. Neurosurg. PsychiatryHome page
B C P Ghosh, J B Rowe, A J Calder, J R Hodges, and T H Bak
Emotion recognition in progressive supranuclear palsy
J. Neurol. Neurosurg. Psychiatry, October 1, 2009; 80(10): 1143 - 1145.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Neuroradiol.Home page
A. Erbetta, M.L. Mandelli, M. Savoiardo, M. Grisoli, A. Bizzi, P. Soliveri, L. Chiapparini, S. Prioni, M.G. Bruzzone, and F. Girotti
Diffusion Tensor Imaging Shows Different Topographic Involvement of the Thalamus in Progressive Supranuclear Palsy and Corticobasal Degeneration
AJNR Am. J. Neuroradiol., September 1, 2009; 30(8): 1482 - 1487.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
F. M. O'Keeffe, B. Murray, R. F. Coen, P. M. Dockree, M. A. Bellgrove, H. Garavan, T. Lynch, and I. H. Robertson
Loss of insight in frontotemporal dementia, corticobasal degeneration and progressive supranuclear palsy
Brain, March 1, 2007; 130(3): 753 - 764.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
R. R. Davies, C. M. Kipps, J. Mitchell, J. J. Kril, G. M. Halliday, and J. R. Hodges
Progression in Frontotemporal Dementia: Identifying a Benign Behavioral Variant by Magnetic Resonance Imaging
Arch Neurol, November 1, 2006; 63(11): 1627 - 1631.
[Abstract] [Full Text] [PDF]

Home page
 J. Neurol. Neurosurg. PsychiatryHome page
A Padovani, B Borroni, S M Brambati, C Agosti, M Broli, R Alonso, P Scifo, G Bellelli, A Alberici, R Gasparotti, et al.
Diffusion tensor imaging and voxel based morphometry study in early progressive supranuclear palsy
J. Neurol. Neurosurg. Psychiatry, April 1, 2006; 77(4): 457 - 463.
[Abstract] [Full Text] [PDF]

Home page
 BrainHome page
D. C. Paviour, S. L. Price, M. Jahanshahi, A. J. Lees, and N. C. Fox
Longitudinal MRI in progressive supranuclear palsy and multiple system atrophy: rates and regions of atrophy
Brain, April 1, 2006; 129(4): 1040 - 1049.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.