Brain Advance Access published online on July 20, 2005
Brain, doi:10.1093/brain/awh595
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Neurosurgery, University of Glasgow, Institute of Neurological Sciences, Southern General Hospital, Glasgow, UK
* To whom correspondence should be addressed. Previous preliminary studies have suggested that possession of the APOE
Received December 21, 2004
Revised June 15, 2005
Accepted June 20, 2005
Article
The association between APOE
4, age and outcome after head injury: a prospective cohort study
2 Public Health Sciences, Division of Community Health Sciences, University of Edinburgh Medical School, Edinburgh, UK
3 Clinical Neurosciences, University of Southampton, Southampton General Hospital, Southampton, UK
J. A. R. Nicoll, E-mail: J.Nicoll{at}soton.ac.uk
Abstract 
4 allele is associated with a poor outcome after head injury. This study was designed to confirm and extend those observations in a larger study with examination of additional variables. We prospectively identified admissions to a Neurosurgical Unit for head injury, collected demographic and clinical data, determined APOE genotypes and obtained follow-up information at 6 months. A total of 1094 subjects were enrolled (age range: 0-93 years, mean 37 years). Outcome was assessed using the Glasgow Outcome Scale. There was no overall association between APOE genotype and outcome, with 36% of APOE 4 carriers having an unfavourable outcome compared with 33% of non-carriers of APOE 4. However, there was evidence of an interaction between age and APOE genotype on outcome (P = 0.007) such that possession of APOE 4 reduced the prospect of a favourable outcome in children and young adults. The influence of APOE genotype in younger patients after head injury can be expressed as, at age <15 years, carriage of APOE 4 being equivalent to ageing by 25 years. This finding is consistent with experimental data suggesting that the effect of APOE genotype on outcome after head injury may be expressed through the processes of repair and recovery.
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  T. W Teasdale The apolipoprotein-{varepsilon}4 gene: always harmful? J. Neurol. Neurosurg. Psychiatry, April 1, 2008; 79(4): 364 - 365. [Full Text] [PDF]
|
|
|
|
|
|
A H P W.-v. Son, G M Ribbers, W C J Hop, C M van Duijn, and H J Stam Association between apolipoprotein-{varepsilon}4 and long-term outcome after traumatic brain injury J. Neurol. Neurosurg. Psychiatry, April 1, 2008; 79(4): 426 - 430. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Rapoport, U. Wolf, N. Herrmann, A. Kiss, P. Shammi, M. Reis, A. Phillips, and A. Feinstein Traumatic Brain Injury, Apolipoprotein E-{epsilon}4, and Cognition in Older Adults: A Two-Year Longitudinal Study J Neuropsychiatry Clin Neurosci, February 1, 2008; 20(1): 68 - 73. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S D. Han, A. I Drake, L. M Cessante, A. J Jak, W. S Houston, D. C Delis, J V. Filoteo, and M. W Bondi Apolipoprotein E and traumatic brain injury in a military population: evidence of a neuropsychological compensatory mechanism? J. Neurol. Neurosurg. Psychiatry, October 1, 2007; 78(10): 1103 - 1108. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. A. Lanterna, Y. Ruigrok, S. Alexander, J. Tang, F. Biroli, L. T. Dunn, and W. S. Poon Meta-analysis of APOE genotype and subarachnoid hemorrhage: Clinical outcome and delayed ischemia Neurology, August 21, 2007; 69(8): 766 - 775. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Wilson and H. Montgomery Impact of genetic factors on outcome from brain injury Br. J. Anaesth., July 1, 2007; 99(1): 43 - 48. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Ponsford, D. Rudzki, K. Bailey, and K. T. Ng Impact of apolipoprotein gene on cognitive impairment and recovery after traumatic brain injury Neurology, February 20, 2007; 68(8): 619 - 620. [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Kuroda, M. E. Weck, J. F. Sarwark, A. Hamidullah, and M. S. Wainwright Association of Apolipoprotein E Genotype and Cerebral Palsy in Children Pediatrics, February 1, 2007; 119(2): 306 - 313. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N A Martinez-Gonzalez and C L M Sudlow Effects of apolipoprotein E genotype on outcome after ischaemic stroke, intracerebral haemorrhage and subarachnoid haemorrhage J. Neurol. Neurosurg. Psychiatry, December 1, 2006; 77(12): 1329 - 1335. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M Ariza, R Pueyo, M d. M Matarin, C Junque, M Mataro, I Clemente, P Moral, M A Poca, A Garnacho, and J Sahuquillo Influence of APOE polymorphism on cognitive and behavioural outcome in moderate and severe traumatic brain injury J. Neurol. Neurosurg. Psychiatry, October 1, 2006; 77(10): 1191 - 1193. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H Houlden and R Greenwood Apolipoprotein E4 and traumatic brain injury J. Neurol. Neurosurg. Psychiatry, October 1, 2006; 77(10): 1106 - 1107. [Full Text] [PDF]
|
|