Brain Advance Access published online on September 29, 2005
Brain, doi:10.1093/brain/awh628
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
1 Department of Neurology, University of California, San Francisco, CA, USA; UCSF Memory and Aging Center, San Francisco Veterans Affairs Hospital, San Francisco, CA, USA
* To whom correspondence should be addressed. Neurodegenerative diseases are associated with profound changes in social and emotional function. The emergence of increasingly sophisticated methods for measuring brain volume has facilitated correlation of local changes in tissue content with cognitive and behavioural changes in neurodegenerative disease. The current study examined neuroanatomical correlates of behavioural abnormalities, as measured by the Neuropsychiatric Inventory, in 148 patients with dementia using voxel-based morphometry. Of 12 behaviours examined, 4 correlated with tissue loss: apathy, disinhibition, eating disorders and aberrant motor behaviour. Increasing severity across these four behaviours was associated with tissue loss in the ventral portion of the right anterior cingulate cortex (vACC) and adjacent ventromedial superior frontal gyrus (vmSFG), the right ventromedial prefrontal cortex (VMPC) more posteriorly, the right lateral middle frontal gyrus, the right caudate head, the right orbitofrontal cortex and the right anterior insula. In addition, apathy was independently associated with tissue loss in the right vmSFG, disinhibition with tissue loss in the right subgenual cingulate gyrus in the VMPC, and aberrant motor behaviour with tissue loss in the right dorsal ACC and left premotor cortex. These data strongly support the involvement of the right hemisphere in mediating social and emotional behaviour and highlight the importance of distinct regions on the medial wall of the right frontal lobe in regulating different behaviours. Furthermore, the findings underscore the utility of studying patients with dementia for understanding the neuroanatomical basis of social and emotional functions.
Received November 5, 2004
Revised July 28, 2005
Accepted July 29, 2005
Article
Neuroanatomical correlates of behavioural disorders in dementia
2 Department of Neurology, University of California, San Francisco, CA, USA; UCSF Memory and Aging Center, San Francisco Veterans Affairs Hospital, San Francisco, CA, USA; Department of Psychology, University of California, Los Angeles, CA, USA
3 Department of Neurology, University of California, San Francisco, CA, USA; Department of Radiology, University of California, San Francisco, CA, USA; Magnetic Resonance Imaging Unit, San Francisco Veterans Affairs Hospital, San Francisco, CA, USA
Howard J. Rosen, E-mail: hrosen{at}memory.ucsf.edu
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. L. Whitwell, S. A. Przybelski, S. D. Weigand, R. J. Ivnik, P. Vemuri, J. L. Gunter, M. L. Senjem, M. M. Shiung, B. F. Boeve, D. S. Knopman, et al. Distinct anatomical subtypes of the behavioural variant of frontotemporal dementia: a cluster analysis study Brain, November 1, 2009; 132(11): 2932 - 2946. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. R. Spiegel, J. Kim, K. Greene, C. Conner, and D. Zamfir Apathy Due to Cerebrovascular Accidents Successfully Treated With Methylphenidate: A Case Series J Neuropsychiatry Clin Neurosci, May 1, 2009; 21(2): 216 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Chan, V. Anderson, Y. Pijnenburg, J. Whitwell, J. Barnes, R. Scahill, J. M. Stevens, F. Barkhof, P. Scheltens, M. N. Rossor, et al. The clinical profile of right temporal lobe atrophy Brain, May 1, 2009; 132(5): 1287 - 1298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. M. Kipps, P. J. Nestor, J. Acosta-Cabronero, R. Arnold, and J. R. Hodges Understanding social dysfunction in the behavioural variant of frontotemporal dementia: the role of emotion and sarcasm processing Brain, March 1, 2009; 132(3): 592 - 603. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Zahn, J. Moll, V. Iyengar, E. D. Huey, M. Tierney, F. Krueger, and J. Grafman Social conceptual impairments in frontotemporal lobar degeneration with right anterior temporal hypometabolism Brain, March 1, 2009; 132(3): 604 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. H. Rudebeck, D. M. Bannerman, and M. F. S. Rushworth The contribution of distinct subregions of the ventromedial frontal cortex to emotion, social behavior, and decision making Cogn Affect Behav Neurosci, December 1, 2008; 8(4): 485 - 497. [Abstract] [PDF]
|
|
|
|
|
|
E. D. Huey, R. Zahn, F. Krueger, J. Moll, D. Kapogiannis, E. M. Wassermann, and J. Grafman A Psychological and Neuroanatomical Model of Obsessive-Compulsive Disorder J Neuropsychiatry Clin Neurosci, November 1, 2008; 20(4): 390 - 408. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Zamboni, E. D. Huey, F. Krueger, P. F. Nichelli, and J. Grafman Apathy and disinhibition in frontotemporal dementia: Insights into their neural correlates Neurology, September 2, 2008; 71(10): 736 - 742. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Bruen, W. J. McGeown, M. F. Shanks, and A. Venneri Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease Brain, September 1, 2008; 131(9): 2455 - 2463. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. F. Mendez, E. A. Licht, and J. S. Shapira Changes in Dietary or Eating Behavior in Frontotemporal Dementia Versus Alzheimer's Disease American Journal of Alzheimer's Disease and Other Dementias, June 1, 2008; 23(3): 280 - 285. [Abstract] [PDF]
|
|
|
|
|
|
M. Hoefer, S. C. Allison, G. F. Schauer, J. M. Neuhaus, J. Hall, J. N. Dang, M. W. Weiner, B. L. Miller, and H. J. Rosen Fear conditioning in frontotemporal lobar degeneration and Alzheimer's disease Brain, June 1, 2008; 131(6): 1646 - 1657. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. F. Mendez, E. C. Lauterbach, S. M. Sampson, and ANPA Committee on Research An Evidence-Based Review of the Psychopathology of Frontotemporal Dementia: A Report of the ANPA Committee on Research J Neuropsychiatry Clin Neurosci, May 1, 2008; 20(2): 130 - 149. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S X Xie, M S Forman, J Farmer, P Moore, Y Wang, X Wang, C M Clark, H B Coslett, A Chatterjee, S E Arnold, et al. Factors associated with survival probability in autopsy-proven frontotemporal lobar degeneration J. Neurol. Neurosurg. Psychiatry, February 1, 2008; 79(2): 126 - 129. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Hallam, N. D. Silverberg, A. K. LaMarre, I. R. A. Mackenzie, and H. H. Feldman Clinical Presentation of Prodromal Frontotemporal Dementia American Journal of Alzheimer's Disease and Other Dementias, January 1, 2008; 22(6): 456 - 467. [Abstract] [PDF]
|
|
|
|
|
|
G.D. Rabinovici, W.W. Seeley, E.J. Kim, M.L. Gorno-Tempini, K. Rascovsky, T.A. Pagliaro, S.C. Allison, C. Halabi, J.H. Kramer, J.K. Johnson, et al. Distinct MRI Atrophy Patterns in Autopsy-Proven Alzheimer's Disease and Frontotemporal Lobar Degeneration American Journal of Alzheimer's Disease and Other Dementias, January 1, 2008; 22(6): 474 - 488. [Abstract] [PDF]
|
|
|
|
 |
|
 G. A. Marshall, L. Monserratt, D. Harwood, M. Mandelkern, J. L. Cummings, and D. L. Sultzer Positron Emission Tomography Metabolic Correlates of Apathy in Alzheimer Disease Arch Neurol, July 1, 2007; 64(7): 1015 - 1020. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Amici, S. M. Brambati, D. P. Wilkins, J. Ogar, N. L. Dronkers, B. L. Miller, and M. L. Gorno-Tempini Anatomical Correlates of Sentence Comprehension and Verbal Working Memory in Neurodegenerative Disease J. Neurosci., June 6, 2007; 27(23): 6282 - 6290. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. J Eslinger, P. Moore, V. Troiani, S. Antani, K. Cross, S. Kwok, and M. Grossman Oops! Resolving social dilemmas in frontotemporal dementia J. Neurol. Neurosurg. Psychiatry, May 1, 2007; 78(5): 457 - 460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-T. Du, N. Schuff, J. H. Kramer, H. J. Rosen, M. L. Gorno-Tempini, K. Rankin, B. L. Miller, and M. W. Weiner Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia Brain, April 1, 2007; 130(4): 1159 - 1166. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. L. Miller, K. A. Josephs Jr, J. E. Parisi, and B. M. Keegan A 34-year-old man with progressive behavioral and language disturbance Neurology, January 2, 2007; 68(1): 68 - 74. [Full Text] [PDF]
|
|
|
|
|
|
I. L. Ber, E. Guedj, A. Gabelle, P. Verpillat, M. Volteau, C. Thomas-Anterion, M. Decousus, D. Hannequin, P. Vera, L. Lacomblez, et al. Demographic, neurological and behavioural characteristics and brain perfusion SPECT in frontal variant of frontotemporal dementia. Brain, November 1, 2006; 129(Pt 11): 3051 - 3065. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Garrard and E. Carroll Lost in semantic space: a multi-modal, non-verbal assessment of feature knowledge in semantic dementia Brain, May 1, 2006; 129(5): 1152 - 1163. [Abstract] [Full Text] [PDF]
|
|