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Brain Advance Access published online on June 7, 2006
Brain, doi:10.1093/brain/awl151
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© The Author (2006). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received December 24, 2005
Revised May 5, 2006
Accepted May 9, 2006

Article

The role of corticothalamic coupling in human temporal lobe epilepsy

Maxime Guye 1, Jean Régis 2, Manabu Tamura 2, Fabrice Wendling 3, Aileen McGonigal 1, Patrick Chauvel 1, and Fabrice Bartolomei 1 *

1 Service de Neurophysiologie Clinique, Unité "Epilepsy and Cognition" INSERM U751, CHU TIMONE et Université de la Méditerranée, Marseille, France
2 Service de Neurochirurgie Fonctionnelle et Stéréotaxique, La Timone, Marseille, France
3 Laboratoire Traitement du Signal et de L'Image, INSERM U642, Université de Rennes 1, Campus de Beaulieu, Rennes Cedex, France

* To whom correspondence should be addressed.
Fabrice Bartolomei, E-mail: fbartolo{at}medecine.univ-mrs.fr


  Abstract

The EEG activity of the thalamus and temporal lobe structures (hippocampus, entorhinal cortex and neocortex) was obtained using intracerebral recordings (stereoelectroencephalography, SEEG) performed in patients with TLE seizures undergoing pre-surgical evaluation. Synchrony was studied using a statistical measure of SEEG signal interdependencies (non-linear correlation). The results demonstrated an overall increase of synchrony between the thalamus and temporal lobe structures during seizures. Moreover, although there was great inter-individual variability, we found that values from seizure onset period were significantly higher than values from the background period (P = 0.001). Values at the end of seizure were significantly higher than values from the seizure onset (P < 0.0001). Several indices were also defined in order to correlate some clinical features to the degree of coupling between cortical structures and the thalamus. In patients with mesial TLE seizures, a correlation was found between the degree of thalamocortical synchrony and the presence of an early loss of consciousness but not with other clinical parameters. In addition, surgical prognosis seemed better in patients with low values of thalamocortical couplings at the seizure onset. This report demonstrates that the thalamus and remote cortical structures synchronize their activity during TLE seizures and suggest that the extension of the epileptogenic network to the thalamus is a potential important factor determining surgical prognosis.

Keywords: temporal lobe; epilepsy; partial seizures; signal processing; thalamus.
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