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Brain Advance Access first published online on September 26, 2006
This version published online on September 29, 2006
Brain, doi:10.1093/brain/awl259
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© The Author (2006). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received April 11, 2006
Revised August 16, 2006
Accepted August 18, 2006

Article

Time-frequency analysis reveals decreased high-frequency oscillations in writer's cramp

Zoé Cimatti 1 *, Denis P. Schwartz 2, Frédéric Bourdain 3, Sabine Meunier 4, Jean-Pierre Bleton 5, Marie Vidailhet 6, Bernard Renault 7, and Line Garnero 7

1 Pierre & Marie Curie University, Pitié-Salpêtrière Hospital, Paris, France; Cognitive Neuroscience & Brain Imaging Laboratory, Pitié-Salpêtrière Hospital, Paris, France
2 MEEG Center, Pitié-Salpêtrière Hospital, Paris, France
3 Neurology Department, Saint Antoine Hospital, Paris, France
4 Physiology and Physiopathology of Motor Control in Humans Laboratory, Saint Anne Hospital, Paris, France
5 Neurology Department, Raymond Garcin Center, Saint Anne Hospital, Paris, France
6 Pierre & Marie Curie University, Pitié-Salpêtrière Hospital, Paris, France; Neurology Department, Saint Antoine Hospital, Paris, France; Experimental Neurology and Therapeutics Laboratory, Paris, France
7 Cognitive Neuroscience & Brain Imaging Laboratory, Pitié-Salpêtrière Hospital, Paris, France

* To whom correspondence should be addressed.
Zoé Cimatti, E-mail: cimatti{at}chups.jussieu.fr


  Abstract

High-frequency oscillations (HFO) have been suggested to reflect the activity of thalamocortical and/or intracortical neurons bursting at high frequencies. These circuits seem to be involved in pathophysiological mechanisms of focal dystonia. In healthy subjects, we characterized the spectrotemporal properties of HFO patterns evoked by dominant-hand median-nerve stimulation, using magnetoencephalography coupled with time-frequency analysis. Then, we investigated HFO in patients with writer's cramp and found that HFO patterns are strongly decreased in power and disorganized in time. This supports the assumption that abnormal HFOs reflect pathophysiological mechanisms occurring in focal dystonia, possibly resulting from a dysfunction of somatosensory processing.

Keywords: high-frequency oscillations; dystonia; time-frequency analysis; MEG; somatosensory evoked fields.
This is a corrected version of the article as it includes the full author list of authors and affiliations.
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Diffusion Abnormalities in the Primary Sensorimotor Pathways in Writer's Cramp
Arch Neurol, April 1, 2009; 66(4): 502 - 508.
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