Skip Navigation



Brain Advance Access published online on October 3, 2006
Brain, doi:10.1093/brain/awl274
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
129/11/2867    most recent
awl274v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Apostolova, L. G.
Right arrow Articles by Thompson, P. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Apostolova, L. G.
Right arrow Articles by Thompson, P. M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author (2006). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Received June 7, 2006
Revised August 31, 2006
Accepted August 31, 2006

Article

3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease

Liana G. Apostolova 1 *, Ivo D. Dinov 2, Rebecca A. Dutton 3, Kiralee M. Hayashi 3, Arthur W. Toga 1, Jeffrey L. Cummings 4, and Paul M. Thompson 1

1 Department of Neurology, David Geffen School of Medicine, UCLA, CA, USA; Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, CA, USA
2 Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, CA, USA; Department of Statistics, David Geffen School of Medicine, UCLA, CA, USA
3 Laboratory of Neuro Imaging, David Geffen School of Medicine, UCLA, CA, USA
4 Department of Neurology, David Geffen School of Medicine, UCLA, CA, USA; Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, UCLA, CA, USA

* To whom correspondence should be addressed.
Liana G. Apostolova, E-mail: lapostolova{at}mednet.ucla.edu


  Abstract

Alzheimer's disease is the most common neurodegenerative disorder in the elderly. Amnestic mild cognitive impairment (MCI) is a relatively newly defined clinical entity that requires memory decline while activities of daily living remain intact. Most amnestic MCI patients develop Alzheimer's disease. Using an innovative surface-based hippocampal analytic technique we analysed the structural magnetic resonance hippocampal data of 31 amnestic MCI and 34 Alzheimer's disease subjects. We tested the hypothesis that Alzheimer's disease subjects have greater atrophy of the CA1, CA2 and CA3 hippocampal subfields relative to amnestic MCI subjects. 3D hippocampal maps localized the main group differences to the CA1 region bilaterally and the CA2 and CA3 region on the right (left P = 0.0024, right P = 0.0002, both corrected for multiple comparisons). Age, race, gender, education and Mini-Mental State Examination were significant predictors of hippocampal volume. Hippocampal volume was a significant predictor of clinical diagnosis. Our study suggests that as Alzheimer's disease progresses, subregional hippocampal atrophy spreads in a pattern that follows the known trajectory of neurofibrillary tangle dissemination. Novel hippocampal analytic techniques that can track the spread of hippocampal pathology in 3D with such precision are a promising research tool.

Keywords: hippocampus; atrophy; Alzheimer's disease; mild cognitive impairment.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Arch NeurolHome page
E. D. Louis, A. M. Brickman, C. DeCarli, S. A. Small, K. Marder, N. Schupf, and T. R. Brown
Quantitative Brain Measurements in Community-Dwelling Elderly Persons With Mild Parkinsonian Signs
Arch Neurol, December 1, 2008; 65(12): 1649 - 1654.
[Abstract] [Full Text] [PDF]

Home page
 NeurologyHome page
A. S. Fleisher, S. Sun, C. Taylor, C. P. Ward, A. C. Gamst, R. C. Petersen, C. R. Jack Jr, P. S. Aisen, L. J. Thal, and For the Alzheimer's Disease Cooperative Study
Volumetric MRI vs clinical predictors of Alzheimer disease in mild cognitive impairment
Neurology, January 15, 2008; 70(3): 191 - 199.
[Abstract] [Full Text] [PDF]

Home page
 Arch NeurolHome page
L. G. Apostolova, C. A. Steiner, G. G. Akopyan, R. A. Dutton, K. M. Hayashi, A. W. Toga, J. L. Cummings, and P. M. Thompson
Three-Dimensional Gray Matter Atrophy Mapping in Mild Cognitive Impairment and Mild Alzheimer Disease
Arch Neurol, October 1, 2007; 64(10): 1489 - 1495.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.