Brain Advance Access published online on May 29, 2007
Brain, doi:10.1093/brain/awm113
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Mechanisms of body weight gain in patients with Parkinson's disease after subthalamic stimulation
1INRA, Centre Clermont-Ferrand – Theix, UMR 1019, Unité de Nutrition Humaine, CRNH Auvergne, Clermont-Ferrand, F-63009 France, 2Univ Clermont 1, UFR Médecine, UMR 1019, Unité de Nutrition Humaine, CRNH Auvergne, CHRU, Clermont-Ferrand, F-63009 France and 3Univ Clermont 1, UFR Médecine, Department of Neurology, Gabriel Montpied Hospital, Clermont-Ferrand, F-63003 France
Correspondence to:
F. Durif, MD PhD, Department of Neurology, Gabriel Montpied Hospital, BP 69, Clermont-Ferrand 63003 Cedex 1, France E-mail: fdurif{at}chu-clermontferrand.fr
Chronic bilateral subthalamic stimulation leads to a spectacular clinical improvement in patients with motor complications. However, the post-operative body weight gain involved may limit the benefits of surgery and induce critical metabolic disorders. Twenty-four Parkinsonians (61.1 ± 1.4 years) were examined 1 month before (M – 1) and 3 months after (M + 3) surgery. Body composition and energy expenditure (EE) were measured (1) over 36 h in calorimetric chambers (CC) with rigorous control of food intakes and activities [sleep metabolic rate, resting activities, meals, 3 or 4 sessions of 20 min on a training bicycle at 13 km/h and daily EE] and (2) in resting conditions (basal metabolic rate) during an acute L-dopa challenge (M – 1) or according to acute ‘off’ and ‘on’ stimulation (M + 3). Before surgery, EE was compared between the Parkinsonian patients and healthy subjects matched for height and body composition (metabolic rate during sleep, daily EE) or matched to predicted values (basal metabolic rate).
Before surgery, in Parkinsonian men but not women, (1) daily EE was higher while sleep metabolic rate was lower compared to healthy matched men (+9.2 ± 3.9 and –8.2 ± 2.3%, respectively, P < 0.05) and (2) basal metabolic rate (L-dopa ‘on’) was higher than predicted basal metabolic rate (+11.5 ± 4.0%, P < 0.05) but was further increased without L-dopa (+8.4 ± 3.2% vs L-dopa ‘on’, P < 0.05). EE during daily activities was higher during ‘off’ periods compared to ‘on’ periods for both men (+19.3 ± 3.3%, P < 0.0001) and women (+16.1 ± 4.7%, P < 0.01). After surgery, there was a 3.4 ± 0.6 kg (P < 0.0001) body weight increase together with fat mass (P < 0.0001) and fat-free mass (P < 0.05) in Parkinsonian men and a 2.6 ± 0.8 kg (P < 0.05) body weight increase together with fat mass (P < 0.05) in Parkinsonian women. Sleep metabolic rate increased in men (+7.5 ± 2.0%, P < 0.01) to reach control values but remained unchanged in women. Daily EE decreased significantly in both men and women (–7.3 ± 2.2% and –13.1 ± 1.7%, respectively, P < 0.01) but there was no correlation between daily EE changes and body weight gain.
Parkinson's disease is associated with profound alterations in the central control of energy metabolism. Normalization of energy metabolism after DBS-STN implantation may favour body weight gain, of which quality was gender specific. As men gained primarily fat-free mass, a reasonable weight gain may be tolerated, in contrast with women who gained only fat. Other factors such as changes in free-living physical activity may help to limit body weight gain in some patients.
Key Words: energy metabolism; metabolic syndrome; chronic bilateral subthalamic stimulation; Parkinson's disease
Abbreviations: BMR, basal metabolic rate; DBS, deep brain stimulation; EE, energy expenditure; LIDs, L-dopa-induced dyskinesias; SMR, sleep metabolic rate; STN, subthalamic nucleus
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Received November 16, 2006. Revised April 17, 2007. Accepted April 19, 2007.
*These authors contributed equally to this work.
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