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Brain Advance Access first published online on March 17, 2009
This version published online on April 1, 2009
Brain, doi:10.1093/brain/awp034
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© The Author (2009). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Evaluation of evoked potentials to dyadic tones after cochlear implantation

Pascale Sandmann1, Tom Eichele2, Michael Buechler3, Stefan Debener4,5, Lutz Jäncke1, Norbert Dillier3, Kenneth Hugdahl2,6 and Martin Meyer1

1 Institute of Psychology, Division of Neuropsychology, University of Zurich, Switzerland 2 Department of Biological and Medical Psychology, University of Bergen, Norway 3 ENT Department, University Hospital Zurich, Zurich, Switzerland 4 MRC Institute of Hearing Research, Southampton, UK 5 Biomagnetic Centre, Department of Neurology, University Hospital Jena, Germany 6 Division of Psychiatry, Haukeland University Hospital, Bergen, Norway

Correspondence to: Pascale Sandmann, MSc, Institute of Psychology, Division of Neuropsychology, University of Zurich, Switzerland E-mail: p.sandmann{at}psychologie.uzh.ch

Auditory evoked potentials are tools widely used to assess auditory cortex functions in clinical context. However, in cochlear implant users, electrophysiological measures are challenging due to implant-created artefacts in the EEG. Here, we used independent component analysis to reduce cochlear implant-related artefacts in event-related EEGs of cochlear implant users (n = 12), which allowed detailed spatio-temporal evaluation of auditory evoked potentials by means of dipole source analysis. The present study examined hemispheric asymmetries of auditory evoked potentials to musical sounds in cochlear implant users to evaluate the effect of this type of implantation on neuronal activity. In particular, implant users were presented with two dyadic tonal intervals in an active oddball design and in a passive listening condition. Principally, the results show that independent component analysis is an efficient approach that enables the study of neurophysiological mechanisms of restored auditory function in cochlear implant users. Moreover, our data indicate altered hemispheric asymmetries for dyadic tone processing in implant users compared with listeners with normal hearing (n = 12). We conclude that the evaluation of auditory evoked potentials are of major relevance to understanding auditory cortex function after cochlear implantation and could be of substantial clinical value by indicating the maturation/reorganization of the auditory system after implantation.

Key Words: cochlear implant; event-related potentials; hemispheric asymmetry; plasticity; independent component analysis

Received August 5, 2008. Revised January 13, 2009. Accepted January 28, 2009.


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