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Brain Advance Access published online on June 24, 2009
Brain, doi:10.1093/brain/awp150
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© The Author (2009). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Parkinson's disease, DBS and suicide: a role for serotonin?

Yasin Temel1, Sonny Tan1, Veerle Visser-Vandewalle1 and Trevor Sharp2

1 Departments of Neuroscience and Neurosurgery, Maastricht University Medical Center, Maastricht, The Netherlands 2 Department of Pharmacology, University of Oxford, UK

Correspondence to: Y. Temel, Department of Neurosurgery, University Hospital Maastricht, P. Debyelaan 25, 6202 AZ Maastricht, The Netherlands E-mail: y.temel@np.unimaas.nl

Received March 10, 2009. Accepted May 4, 2009.

The first 10% of the full text of this article appears below.

Sir, High frequency deep brain stimulation (DBS) of the sub-thalamic nucleus (STN) using surgically implanted electrodes is an effective treatment of advanced and otherwise treatment-resistant Parkinson's disease (Kumar et al., 1999Go; Krack et al., 2003Go; Rodriguez-Oroz et al., 2005Go; Visser-Vandewalle et al., 2005Go; Deuschl et al., 2006Go). Despite having important beneficial motor effects, STN DBS can be associated with unpleasant and debilitating . . . [Full Text of this Article]


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