Brain Advance Access published online on June 24, 2009
Brain, doi:10.1093/brain/awp151
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© The Author (2009). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org
Parkinson's disease, DBS and suicide: a role for serotonin?
1 National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA 2 Division of Neurology, Department of Medicine, University of Toronto, UHN, Toronto, Canada 3 Department of Neurology, University Joseph Fourier, Grenoble, France 4 Clinique Neurologique, Lille University Hospital, Lille, France 5 National Institute of Health and Medical Research (INSERM), Hôpital de la Pitié-Salpêtrière, Paris, France 6 Department of Neurology, Université Lyon I, Hospital Neurologique Pierre Wertheimer, Lyon, France 7 Department of Neurology, University of Milan, Italy 8 Department of Neurology, Christian-Albrechts-Universität Kiel, Kiel, Germany 9 Academic Medical Center of Amsterdam, Amsterdam, The Netherlands 10 Department of Psychiatry and Psychology, University of Arizona, Phoenix, AZ, USA 11 The Cleveland Clinic Foundation, OH, USA
Correspondence to:
Dr Valerie Voon, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Building 10, Room 5S213, Bethesda, MD 20892-1428, USA E-mail: voonv@ninds.nih.gov
Received May 7, 2009. Accepted May 7, 2009.
| The first 10% of the full text of this article appears below. |
We would like to thank Temel et al. for their communication highlighting the potential role of serotonin and suicidal behaviours, which are intriguing and potentially of relevance. Temel et al. have previously shown that subthalamic nucleus (STN) HFS in a rat study inhibits serotonergic dorsal raphe firing rate and elicits depressive-like behaviour which can be prevented with pre-treatment with a serotonin reuptake inhibitor (Temel et al., 2007
). Post-mortem and biological challenge studies suggest serotonergic hyporesponsivity particularly in suicide attempts of high lethality and lower prefrontal serotonin receptor density with a compensatory increase in midbrain serotonin neuron density and function (Mann et al., 1996; Oquendo et al., 2003; Boldrini et al., 2008).
Temel et al. point to