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Differential activation of the prefrontal cortex in successful and unsuccessful memory retrieval

M. D. Rugg, P. C. Fletcher, C. D. Frith, R. S. J. Frackowiak, R. J. Dolan
DOI: http://dx.doi.org/10.1093/brain/119.6.2073 2073-2083 First published online: 1 December 1996


Six subjects underwent PET scans while they performed three versions of a recognition memory test for words and three versions of a control task. In each memory condition, the subjects discriminated between words presented in a prescan study list and words new to the experiment. During the 30 s scanning interval, the ratio of old and new words was 0: 20, 4: 16 or 16: 4, depending on the experimental condition. Outside this interval, the ratio was 50: 50 in all three conditions. The requirement in the control task was to discriminate between two character strings, the ratios of which were also manipulated during the 30 s scanning interval. Employing the control task as a covariate, analysis with statistical parametric mapping revealed that regional cerebral blood flow (rCBF) covaried with increasing density of old items in three regions of prefrontal cortex: right dorsolateral [Brodmann area (BA) 9/46], right medial (BA 32/8) and bilateral frontopolar cortex (BA 10). It is concluded that the prefrontal cortex, especially in the right hemisphere, is more active when a retrieval attempt succeeds than when it fails. This finding is consistent with the idea that the prefrontal cortex supports processes that operate selectively on the products of memory retrieval.

  • episodic memory
  • memory retrieval
  • prefrontal cortex
  • recognition memory