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Platelet-derived growth factor-BB is involved in mesenchymal stem cell secretome-induced neuroprotection of retinal ganglion cells

Jian-Li He
DOI: http://dx.doi.org/10.1093/brain/awu017 e276 First published online: 21 February 2014

Sir, We read with interest the article by Johnson et al. (2014) about the mesenchymal stem cell (MSC) secretome and the significant neuroprotective effects of platelet-derived growth factor (PDGF)-AA and -AB on retinal ganglion cells. However, PDGF-BB was excluded from a major part of the study, without explanation. PDGF-BB (PDGF-AB/BB) was shown to be secreted at significantly higher levels by human MSCs with …

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