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Acute mild traumatic brain injury is not associated with white matter change on diffusion tensor imaging

Tero Ilvesmäki, Teemu M. Luoto, Ullamari Hakulinen, Antti Brander, Pertti Ryymin, Hannu Eskola, Grant L. Iverson, Juha Öhman
DOI: http://dx.doi.org/10.1093/brain/awu095 1876-1882 First published online: 12 May 2014

Summary

This study was designed to (i) evaluate the influence of age on diffusion tensor imaging measures of white matter assessed using tract-based spatial statistics; (ii) determine if mild traumatic brain injury is associated with microstructural changes in white matter, in the acute phase following injury, in a large homogenous sample that was carefully screened for pre-injury medical, psychiatric, or neurological problems; and (iii) examine if injury severity is related to white matter changes. Participants were 75 patients with acute mild traumatic brain injury (age = 37.2 ± 12.0 years, 45 males and 30 females) and 40 controls (age = 40.6 ± 12.2 yrs, 20 males and 20 females). Age effects were analysed by comparing control subgroups aged 31–40, 41–50, and 51–60 years against a group of 18–30-year-old control subjects. Widespread statistically significant areas of abnormal diffusion tensor measures were observed in older groups. Patients and controls were compared using age and gender as covariates and in age- and gender-matched subgroups. Subgroups of patients with more severe injuries were compared to age-and gender-matched controls. No significant differences were detected in patient-control or severity analyses (all P-value > 0.01). In this large, carefully screened sample, acute mild traumatic brain injury was not associated with diffusion tensor imaging abnormalities detectable with tract-based spatial statistics.

  • concussion
  • traumatic brain injury
  • magnetic resonance imaging
  • diffusion tensor imaging
  • statistical analysis
  • Abbreviations
    DTI
    diffusion tensor imaging
    TBI
    traumatic brain injury
    TBSS
    tract-based spatial statistics
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