Cover design Left: Schematic drawing of a chandelier cell. This GABAergic inhibitory interneuron is distinguished by the characteristic terminal portions of its axon, which form short vertical rows of boutons resembling candlesticks (Ch terminals). Each Ch terminal innervates a single axon initial segment of a pyramidal cell and has an important functional role in controlling pyramidal cell activity. Right: Parvalbumin immunostaining through the normal human middle temporal gyrus, showing an immunoreactive neuron and Ch terminals. These cells (among other types) have been found to be lost or reduced at epileptic foci in epileptic patients. It has been hypothesized that the chandelier cell is a key component of cortical circuits in the establishment of human intractable temporal lobe epilepsy. From `Chandelier cells and epilepsy' by J. DeFelipe, 1807-1822.
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