Cover design Light microscopy of two actively demyelinating multiple sclerosis lesions (obtained from different patients) stained for proteolipid protein mRNA cells (black) and proteolipid protein (red). The upper panel demonstrates oligodendrocytes present in the periplaque white matter with loss of proteolipid protein mRNA-expressing oligodendrocytes at the active edge. The lower panel demonstrates many proteolipid protein mRNA-positive oligodendrocytes present within both the periplaque white matter and the plaque itself. From `A quantitative analysis of oligodendrocytes in multiple sclerosis lesions: a study of 113 cases' by C. Lucchinetti et al., 22792295.
[Table of Contents]