Cover design A single carbocyanine dye crystal was placed a few mm away from a heterotopic nodule in deep cerebral white matter from a child with intractable epilepsy. Numerous labelled fibres (orange) closely surround the nodule, but the majority do not penetrate it. A few fibres cross the margin of the nodule and have punctate termini close to cell bodies. Bisbenzimide labelling (blue) reveals the cells within the nodule. The authors examined the cellular and neurochemical composition of heterotopic nodules and describe multiple neuronal cell type with limited connectivity to other brain regions. This abnormal connectivity may affect neuronal maturation and consequently the balance of excitation and inbitition in neuronal circuits, leading to their epileptogenic potential. From `Characterization of nodular neuronal heterotopia in children' by A. J. Hannan
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