About the Cover
Cover design Localization of proteolytic activity by in situ zymography in a muscle biopsy from a patient diagnosed as polymyositis. Upper left: collagenolytic activity is detectable along the sarcolemma (arrows). Lower left: this proteolytic activity is similar in appearance and distribution to the staining pattern for matrix metalloproteinase-1 (arrows) as determined by immunohistochemistry on serial sections. Upper right: gelatinolytic activity appears in round areas (arrows). Lower right: the staining pattern for matrix metalloproteinase-9 (arrows) is similar to the distribution of this proteolytic activity. From `Expression of specific matrix metalloproteinases in inflammatory myopathies' by B. C. Kieseier et al., 341351.
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