COVER ILLUSTRATION. Confocal laser scanning-generated images of oligodendrocyte precursor cells and immature oligodendrocytes in spinal cord multiplesclerosis lesions. Top left: two oligodendrocyte precursor cells, i.e. cells labelled with the O4 antibody (green), but not with antibodies to the oligodendrocyte marker galactocerebroside (blue), in an area with large numbers of demyelinated axons (red). The arrow head points to a process (labelledgreen and blue) of an immature oligodendrocyte that has enwrapped a denuded axon (red). Top right: oligodendrocyte precursor cell (red) in a demyelinated area with numerous activated microglia/macrophages (green). Bottom left: oligodendrocyte precursor cell (red) lacking the astrocyte-specific intermediate filament glial fibrillary acidic (green). Bottom right: immature oligodendrocyte (red) that is in the process of forming new myelin basic protein-positive myelin sheaths (green) around some demyelinated axons (blue). From `Oligodendrocyte precursor cells in the demyelinated spinal cord' by G.Wolswijk et al., pp. 338 -49.
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