COVER ILLUSTRATION. Spinal cord from a patient with Devic's neuromyelitis optica illustrating extensive demyelination involving both grey and white matter (upper left), marked macrophage infiltration (upper right), sharply delineated plaque borders (lower left), and active demyelination with macrophages containing myelin oligodendrocyte glycoprotein debris (lower right). From: 'A role for humoral mechanisms in the pathogenesis of Devic's neuromyelitis optica' by C. F. Lucchinetti et al., pp. 1450 - 61.
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