COVER ILLUSTRATION. Intranuclear inclusions and associated neuropathology in the brains of older male carriers of premutation fragile X alleles. Inclusion formation is associated with a cerebellar tremor/ataxia syndrome among male carriers of the expanded alleles. (Top) Intranuclear neuronal and glial inclusions in cortex (H&E). (Middle left) Scattered axonal torpedoes in the cerebellum (anti-neurofilament antibody). (Middle right) Intranuclear inclusions stained with anti-ubiquitin antobodies. (Bottom) Ubiquitin-positive, intranuclear inclusions in both neurones and glia of the hippocampus. Inclusions are found throughout the brains of affected individuals, with highest numbers (~40%) found in the hippocampus. From `Neuronal intranuclear inclusions in a new cerebellar tremor/ataxia syndrome among fragile X carriers' by C. Greco et al., pp. 1760-1771.
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