COVER ILLUSTRATION. Transverse sections of the sural nerves from Charcot--Marie--Tooth patients. (Top left) Myelinated fibre density is markedly decreased and onion bulb formation is prominent in a patient with PMP22 duplication. (Top right) Axon sprouts are moderately present (arrows) in another patient with PMPP duplication. Onion bulb formation is prominent (bottom left) in a patient with MPZ mutation (Arg98His), while axonal sprouts are abundant (bottom right) in another patient with MPZ mutation (Thr124Met). From `Demyelinating and axonal features of Charcot--Marie--Tooth disease with mutations of myelin-related proteins (PMP22, MPZ and Cx32): a clinicopathological study of 205 Japanese patients' by N. Hattori et al., pp. 134--151.
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