COVER ILLUSTRATION. Autopsy report in an individual admitted in 1897 and dying in 1901 who was noted to have poor memory and an heritable disease. Considered by the pathologist to have ‘organic disease of brain’ with the ‘convolutions markedly atrophied’ and the hemispheres each weighing 13oz, the cerebellum 4oz and the pons and medulla 3/4 oz, this may be the earliest autopsy report of inherited prion disease. The background shows cerebellum with deposition of prion protein (PrP) in the form of plaques, and synaptic and perineuronal staining in the molecular and granular layer as seen in one case from the same family. From Mead et al. pp. 2297–2317. Figure courtesy of West Sussex Record Office.
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