COVER ILLUSTRATION. "Riboflavin sensitive" missense mutations in the ETF: QO structure. Ribbon representation of the ETF: QO protein based on the crystal structure of porcine ETF:QO (Zhang et al., 2006). The 4Fe4S cluster domain is in dark blue, the ubiquinone-binding domain in light blue and the FAD domain in pink. The three redox centers are shown in stick models. The human residues mutated in riboflavin-responsive MADD are shown in space filling. From Olsen et al. ETFDH mutations as a major cause of riboflavin-responsive multiple acyl-CoA dehydrogenation deficiency. pp. 2045–2054.
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