Foreground: Speckle contrast image superimposed on mouse skull. Surface vessels are seen as dark branching structures. Arrows point to the middle cerebral artery branches. Circle and square show the regions of interest used to quantify the cerebral blood flow changes during cortical spreading depression and whisker stimulation, respectively. Dotted line outlines the regions of interest used to quantify the cerebral blood flow changes during hypercapnia. Background: Representative multiphoton images of 8 and 19 month-old Tg2576 brains (bottom-right and top-left, respectively) after topical thioflavin S staining and representative pseudocolor laser speckle flowmetry maps of cerebral blood flow changes. From Shin et al. (pp. 2310-2319)
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