Brain activity in patients with narcolepsy with cataplexy measured whilst watching humorous pictures. Foreground: Stimulus sequences were composed of a neutral scene followed by a second picture revealing a new humourous element. Upper background: Increased amygdala response to humour in narcolepsy with cataplexy patients. Lower background: Increased response to humour in right hypothalamus, medial prefrontal, and cingulate cortex for controls relative to narcolepsy with cataplexy patients. From Schwartz et al. Abnormal activity in hypothalamus and amygdale during humour processing in human narcolepsy with cataplexy pp. 514–522
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